Fast-Track Cities is a global network of more than 600 cities and municipalities exercising urban health leadership to achieve health-related Sustainable Development Goals (SDGs), including in relation to HIV, TB, and viral hepatitis. IAPAC is delivering technical assistance to and engaging in direct interventions across the Fast-Track Cities network. Advanced collaboratively with local stakeholders, our work includes data generation, implementation planning, capacity-building, community engagement, stigma elimination, and quality of care and life assessments. Since 2019, IAPAC has also coordinated the annual (now biennial) series of global Fast-Track Cities conferences convening member-cities and municipalities to share best practices and engage in strategic networking.